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Real-time Raman capability in a sophisticated parallel crystallizer
Parallel Crystallizer with Raman Probe
In addition to providing all the benefits of Technobis’s Crystalline SE (Standard Edition), the advanced Crystalline RR (Raman Ready) incorporates the real-time Raman function. It monitors chemical and morphological changes, providing powerful capabilities in developing and optimizing crystallization processes.
Like other models in the Crystalline range, the RR is a compact yet sophisticated parallel crystallizer suitable for crystallization process development and optimization across a broad range of industries. Its intuitive control and analysis software gives unparalleled access to real-time information on experiments.
- 4 parallel real-time non-intrusive Raman probes perform real-time monitoring of chemical and morphological changes.
- 8 independently programmable reactors with stir bar and/or overhead stirring make it possible to study the effect of different solvents or counter-ions in a simple and easy fashion.
- 8 blocks with independently programmable temperature and stirring control with stir bar enable one system to be used simultaneously by several operators.
- 8 independent non-invasive turbidity probes provide real-time turbidity measurements while avoiding cross-contamination.
- ml-scale reaction saves on samples while compact ergonomic design saves valuable laboratory space.
- Range of crystallization techniques (e.g. cooling, evaporation, anti-solvent addition, etc.) supported.
- Correlation of Raman spectra with temperature profiles and turbidity signals
- Software interface for spectroscopic analysis
- Precise temperature control (0.1 °C) and fast heating / cooling rate
- ml-scale refluxing capability
- ml-scale slow evaporation with N2 flow
- ml-scale seeding capability
- Software for fast report export
- Can mix even the most viscous materials in a controlled fashion
- Feedback control allows response to crystallization events during the temperature cycle
- Expandable to online observation of morphology
- Process development and optimization
- Monitoring chemical reactions
- Monitoring changes in crystal form
- Polymorph/solvate/hydrate/co-crystal screening
- Looking for less stable intermediates
- Controlling growth of certain polymorphs
- Fast solubility curve and MSZW determination